SERC - 2012 - TR - 028 - 1 January 31 , 2012
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منابع مشابه
Genetic Testing for Predisposition to Inherited Hypertrophic Cardiomyopathy
Professional Institutional Original Effective Date: March 26, 2012 Original Effective Date: March 26, 2012 Revision Date(s): April 8, 2013; December 31, 2013; March 31, 2015; January 1, 2016; February 17, 2016; January 1, 2017; April 12, 2017; January 1, 2018 Revision Date(s): April 8, 2013; December 31, 2013; March 31, 2015; January 1, 2016; February 17, 2016; January 1, 2017; April 12, 2017; ...
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Aberrantly expressed tyrosine kinases have emerged as promising targets for drug development in acute myeloid leukemia (AML). We report that AKN-028, a novel tyrosine kinase inhibitor (TKI), is a potent FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor (IC(50)=6 nM), causing dose-dependent inhibition of FLT3 autophosphorylation. Inhibition of KIT autophosphorylation was shown in a human mega...
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تاریخ انتشار 2012